Enhancement of Serotonin 2C Receptor mRNA Expression by Antidepressants Possessing the Receptor-Blocking Activity in the Rat Brain.

• Tohda Michihisa

  Department of Pharmacology, Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University

• Watanabe Hiroshi

  Department of Pharmacology, Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University

書誌事項

タイトル別名

• Enhancement of Serotonin 2C Receptor mR

抄録

The effects of repeated oral administration of antidepressants on the serotonin 2C receptor subtype (5-HT2CR) mRNA level in the rat brain were examined. Imipramine (20 mg/kg, p.o.) enhanced the hybridization signal in a time (days)-dependent manner, reaching a maximum at day 4 and maintaining a high level until day 14. Desipramine and mianserin, which have 5-HT2CR antagonistic activity, also stimulated the mRNA expression to about same extents as imipramine, but nomifensine, which has no effect on 5-HT2CR, was ineffective. These results suggest that long-term treatment with antidepressants, which act as 5-HT2CR antagonists, stimulates 5-HT2CR mRNA expression.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 78 (4), 515-517, 1998

  公益社団法人 日本薬理学会

キーワード

• Serotonin 2C receptor
• Antidepressant
• mRNA expression

詳細情報

• CRID: 1390001204287168128
• NII論文ID: 10008682002
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.78.515
• COI: 1:CAS:528:DyaK1MXhvFWltQ%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4629559
• PubMed: 9920211
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4629559
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310182?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310182?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/78/4/78_4_515/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999118259
• 本文言語コード: en
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