Teprenone, an Anti-ulcer Agent, Increases Gastric Mucosal Mucus Level via Nitric Oxide in Rats.
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- Nishida Keiji
- Department of Biochemistry, School of Medicine, Fujita Health University
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- Ohta Yoshiji
- Department of Biochemistry, School of Medicine, Fujita Health University
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- Ishiguro Isao
- Department of Biochemistry, School of Medicine, Fujita Health University
Bibliographic Information
- Other Title
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- Teprenone an Anti ulcer Agent Increases
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Abstract
We examined whether the increasing action of teprenone (TP) on mucus synthesis and content in rat gastric mucosa is related to nitric oxide (NO) formation via NO synthase (NOS) in the tissue. TP (200 mg/kg)-induced increases in levels of gastric mucosal hexosamine and adherent mucus were inhibited with decreased gastric mucosal NOS activity and nitrite/nitrate concentration by co-administration of NG-monomethyl L-arginine (100 mg/kg), a NOS inhibitor, but not its D-isomer. These results suggest that TP exerts an increasing action on gastric mucus synthesis and content possibly under the condition of maintained NO production via NOS in gastric mucosal tissues, although the precise mechanisms for the action of TP is still unclear.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (4), 519-522, 1998
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679263877760
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- NII Article ID
- 10008682013
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXhvFWlug%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4629560
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- PubMed
- 9920212
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4629560
- https://api.elsevier.com/content/article/PII:S0021519819310194?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310194?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/4/78_4_519/_pdf
- https://search.jamas.or.jp/link/ui/1999112532
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed