Higher Environmental Temperature Potentiates Cataleptic Effect of Fentanyl in Rats

この論文にアクセスする

この論文をさがす

著者

抄録

The influence of higher environmental temperature (HET=30±1°C) on fentanyl-induced behavior was studied in unrestrained rats. Subacute exposure (3 days) of rats to HET significantly (P<0.01) increased the cataleptic effect of fentanyl citrate (0.5 mg/kg), in comparison to the corresponding exposure to normal environmental temperature (NET=22±1°C). Also, the hyperthermic response of rats to a low dose of fentanyl citrate (0.2 - 0.5 mg/kg) was significantly (P<0.01) potentiated, and the hypothermic response to a high dose of fentanyl citrate (1.5 mg/kg) was significantly (P<0.05) attenuated after exposure to HET. Fentanyl-induced hyperexcitability, loss of righting reflex, loss of corneal reflex and analgesia were not significantly affected by HET. This study provides the first evidence on the influence of environmental temperature on drug-induced catalepsy. HET-induced potentiation of the cataleptic response to fentanyl could be the result of an interference with behavioral thermoregulation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 78(4), 523-527, 1998-12-01

    The Japanese Pharmacological Society

参考文献:  23件中 1-23件 を表示

各種コード

  • NII論文ID(NAID)
    10008682029
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4629561
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ