Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice

この論文にアクセスする

この論文をさがす

著者

抄録

We evaluated the antinociceptive effect of <I>Gosha-jinki-gan</I>, a <I>Kampo</I> medicine including processed <I>Aconiti</I> tuber, and its mechanism in streptozotocin-induced diabetic mice. <I>Gosha-jinki-gan</I> (0.1 - 1.0 g/kg, p.o.) showed a more potent antinociceptive effect in diabetic mice than in non-diabetic mice. The antinociceptive effect of <I>Gosha-jinki-gan</I> (0.3 g/kg, p.o.) in diabetic mice was inhibited by administration of either anti-dynorphin antiserum (5 μg, i.t.) or nor-binaltorphimine (10 mg/kg, s.c.), a κ-opioid antagonist. The antinociceptive activity of <I>Gosha-jinki-gan</I> (0.3, 1.0 g/kg, p.o.) was decreased by excluding processed <I>Aconiti</I> tuber. Furthermore, the antinociceptive effect of processed <I>Aconiti</I> tuber (0.03, 0.1 g/kg, p.o.) was also shown to be enhanced in diabetic mice. These results suggest that the increased antinociceptive effect of <I>Gosha-jinki-gan</I> in diabetic mice is partly derived from the action of processed <I>Aconiti</I> tuber and that it is based on stimulation of spinal κ-opioid receptors via dynorphin release. <I>Gosha-jinki-gan</I> was considered useful for treating painful diabetic neuropathy.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(2), 169-175, 1999-02-01

    The Japanese Pharmacological Society

参考文献:  27件中 1-27件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10008682236
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4663447
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ