Benzodiazepine Receptor Agonists Modulate Thymocyte Apoptosis Through Reduction of the Mitochondrial Transmembrane Potential

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抄録

Peripheral-type benzodiazepines have been shown to exert immunological effects. In this study, we examined the effects of the peripheral-type benzodiazepines on murine thymocytes. Murine thymocytes that were incubated with the peripheral-type benzodiazepines underwent apoptosis associated with the collapse of mitochondrial transmembrane potential (Δφ<SUB>m</SUB>). The drugs stimulated dexamethasone- and etoposide-induced apoptosis with the enhanced collapse of Δφ<SUB>m</SUB>. The central-type benzodiazepines had no effect on either the Δφ<SUB>m</SUB> or apoptosis. The reduction of Δφ<SUB>m</SUB> depended on protein synthesis and protein phosphorylation. These results suggest that the immunomodulating effect of benzodiazepines is in part due to the modulation of thymocyte apoptosis associated with the collapse of Δφ<SUB>m</SUB>.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(2), 177-183, 1999-02-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008682264
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4663466
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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