Effects of Exogenous [Arg^8]-Vasopressin on Borderline-Hypertensive Hiroshima Rats

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The interaction between [Arg<SUP>8</SUP>]-vasopressin and a vasopressin receptor antagonist, [d(CH<SUB>2</SUB>)<SUB>5</SUB><SUP>1</SUP>, O-Me-Tyr<SUP>2</SUP>, Arg<SUP>8</SUP>]-vasopressin, was examined in Hiroshima rats and normotensive control rats under pentobarbital anesthesia. [Arg<SUP>8</SUP>]-vasopressin dose-dependently increased the arterial pressure in both the Hiroshima and control rats, the pressor effect being greater in the Hiroshima rats. After the administration of a vasopressin antagonist (0.01 mg/kg), which by itself decreased arterial pressure only in the Hiroshima rats, the dose-response curve for [Arg<SUP>8</SUP>]-vasopressin was much more greatly shifted to the right in the control rats. These results indicate that with or without a vasopressin antagonist, the exogenous [Arg<SUP>8</SUP>]-vasopressin induced more powerful pressor actions in the Hiroshima rats compared to the control rats.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(2), 251-255, 1999-02-01

    The Japanese Pharmacological Society

参考文献:  8件中 1-8件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008682560
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4663655
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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