Effects of Exogenous (Arg8)-Vasopressin on Borderline-Hypertensive Hiroshima Rats.

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  • Teranishi Yasuhiro
    Department of Physiology, Research Institute for Radiation Biology and Medicine, Hiroshima University School of Medicine
  • Kumazaki Tsutomu
    Department of Biochemistry and Biophysics, Research Institute for Radiation Biology and Medicine, Hiroshima University School of Medicine
  • Ozono Ryoji
    Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine
  • Tsuru Hiromichi
    Department of Pharmacology, Toho University School of Medicine

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The interaction between [Arg8]-vasopressin and a vasopressin receptor antagonist, [d(CH2)51, O-Me-Tyr2, Arg8]-vasopressin, was examined in Hiroshima rats and normotensive control rats under pentobarbital anesthesia. [Arg8]-vasopressin dose-dependently increased the arterial pressure in both the Hiroshima and control rats, the pressor effect being greater in the Hiroshima rats. After the administration of a vasopressin antagonist (0.01 mg/kg), which by itself decreased arterial pressure only in the Hiroshima rats, the dose-response curve for [Arg8]-vasopressin was much more greatly shifted to the right in the control rats. These results indicate that with or without a vasopressin antagonist, the exogenous [Arg8]-vasopressin induced more powerful pressor actions in the Hiroshima rats compared to the control rats.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 79 (2), 251-255, 1999

    公益社団法人 日本薬理学会

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