Expression of Granulocyte-Macrophage Colony-Stimulating Factor(GM-CSF)and Its Regulation by Ovarian Steroids in Rat Uterine Stromal Cells
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- Tamura Kazuhiro
- Department of Pharmacology, Tokyo University of Pharmacy & Life Science
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- Kumasaka Kenichi
- Department of Pharmacology, Tokyo University of Pharmacy & Life Science
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- Kogo Hiroshi
- Department of Pharmacology, Tokyo University of Pharmacy & Life Science
書誌事項
- タイトル別名
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- The Expression of Granulocyte-Macrophage Colony-Stimulating Factor(GM-CSF) and Its Regulation by Ovarian Steroids in Rat Uterine Stromal Cells.
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The effects of ovarian steroids on the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in rat uterus were examined. Intense expression of GM-CSF mRNA was dispersedly located in the endometrial-myometrial junction and stroma of the uterus. GM-CSF was immunohistochemically localized in stromal cells and luminal epithelium. Ovariectomy significantly reduced the appearance of GM-CSF-mRNA-positive cells and the levels of expression for GM-CSF mRNA in the whole uterus, whereas treatment with 17β-estradiol (E2) or a combination of E2 and progesterone (P4) for 5 days on ovariectomized animals recruited GM-CSF-mRNA-positive cells and stimulated its expression. The combined treatment with E2 and P4 also stimulates the expression for GM-CSF mRNA and the production of immunoreactive GM-CSF in the stromal tissues. These data suggest that the expression of GM-CSF in uterine stromal cells is partially regulated by ovarian steroids.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 79 (2), 257-262, 1999
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204284608256
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- NII論文ID
- 10008682569
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXhsFykt7w%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4663673
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- PubMed
- 10202863
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4663673
- https://api.elsevier.com/content/article/PII:S0021519819309783?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819309783?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/2/79_2_257/_pdf
- https://search.jamas.or.jp/link/ui/1999157346
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可