Mechanisms Mediating the Vasorelaxing Action of Eugenol, a Pungent Oil, on Rabbit Arterial Tissue

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The inhibitory actions of eugenol on intracellular Ca<SUP>2+</SUP> concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) and the contractions induced by excess extracellular K<SUP>+</SUP> concentration ([K<SUP>+</SUP>]<SUB>o</SUB>) in rabbit thoracic aorta were investigated. Application of excess [K<SUP>+</SUP>]<SUB>o</SUB> solution (30 - 90 mM) produced contraction and increased the intensity of the Ca<SUP>2+</SUP> fluorescence signal. Pretreatment with eugenol (≥0.1 mM) reduced both the amplitude of contraction and the intensity of the Ca<SUP>2+</SUP> fluorescence signal, but the contraction was more strongly affected than the [Ca<SUP>2+</SUP>]<SUB>i</SUB>. Application of eugenol (0.3 mM) to tissue precontracted by 90 mM [K<SUP>+</SUP>]<SUB>o</SUB> solution (immediately after the removal of the 90 mM [K<SUP>+</SUP>]<SUB>o</SUB> solution) slowed the decay of the [Ca<SUP>2+</SUP>]<SUB>i</SUB> signal, but it did not change the rate of relaxation. Carbonyl cyanide <I>m</I>-chlorophenylhydrozone (10 μM), a mitochondrial metabolic inhibitor, produced a reduction in tension despite a slight increase in [Ca<SUP>2+</SUP>]<SUB>i</SUB> when applied to muscle precontracted by 90 mM [K<SUP>+</SUP>]<SUB>o</SUB> solution. These results indicate that eugenol relaxes the rabbit thoracic aorta while suppressing the Ca<SUP>2+</SUP>-sensitivity and both the uptake and extrusion mechanisms for Ca<SUP>2+</SUP>. To judge from the similarities between its actions and those of metabolic inhibitors, eugenol may produce its actions at least partly through metabolic inhibition.

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  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(3), 327-334, 1999-03-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008682832
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4699238
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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