Mechanisms Mediating the Vasorelaxing Action of Eugenol, a Pungent Oil, or Rabbit Arterial Tissue.
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- Nishijima Hiroaki
- Department of Health and Sports Science, Kawasaki University of Medical Welfair
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- Uchida Ryuji
- Department of Oral Surgery, Fukuoka Dental College
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- Kameyama Kimiko
- Department of Pharmacology, Fukuoka Dental College
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- Kawakami Nozomi
- Department of Pharmacology, Fukuoka Dental College
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- Ohkubo Tsuyako
- Department of Pharmacology, Fukuoka Dental College
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- Kitamura Kenji
- Department of Pharmacology, Fukuoka Dental College
Bibliographic Information
- Other Title
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- Mechanisms Mediating the Vasorelaxing Action of Eugenol,a Pungent Oil,on Rabbit Arterial Tissue
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Abstract
The inhibitory actions of eugenol on intracellular Ca2+ concentration ([Ca2+]i) and the contractions induced by excess extracellular K+ concentration ([K+]o) in rabbit thoracic aorta were investigated. Application of excess [K+]o solution (30 - 90 mM) produced contraction and increased the intensity of the Ca2+ fluorescence signal. Pretreatment with eugenol (≥0.1 mM) reduced both the amplitude of contraction and the intensity of the Ca2+ fluorescence signal, but the contraction was more strongly affected than the [Ca2+]i. Application of eugenol (0.3 mM) to tissue precontracted by 90 mM [K+]o solution (immediately after the removal of the 90 mM [K+]o solution) slowed the decay of the [Ca2+]i signal, but it did not change the rate of relaxation. Carbonyl cyanide m-chlorophenylhydrozone (10 μM), a mitochondrial metabolic inhibitor, produced a reduction in tension despite a slight increase in [Ca2+]i when applied to muscle precontracted by 90 mM [K+]o solution. These results indicate that eugenol relaxes the rabbit thoracic aorta while suppressing the Ca2+-sensitivity and both the uptake and extrusion mechanisms for Ca2+. To judge from the similarities between its actions and those of metabolic inhibitors, eugenol may produce its actions at least partly through metabolic inhibition.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 79 (3), 327-334, 1999
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204284982272
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- NII Article ID
- 10008682832
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXitFClt70%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4699238
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- PubMed
- 10230861
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4699238
- https://api.elsevier.com/content/article/PII:S0021519819309515?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819309515?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/3/79_3_327/_pdf
- https://search.jamas.or.jp/link/ui/1999179935
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed