Effects of XT-44, a Phosphodiesterase 4 Inhibitor, in Osteoblastgenesis and Osteoclastgenesis in Culture and Its Therapeutic Effects

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  • Waki Yoshihiro
    Department of Pharmacology, Faculty of Dentistry, Tokyo Medical and Dental University Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science & Technology, Kanazawa University
  • Horita Takashi
    Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science & Technology, Kanazawa University
  • Miyamoto Ken-ichi
    Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science & Technology, Kanazawa University
  • Ohya Keiichi
    Department of Pharmacology, Faculty of Dentistry, Tokyo Medical and Dental University
  • Kasugai Shohei
    Department of Pharmacology, Faculty of Dentistry, Tokyo Medical and Dental University

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  • Effects of XT-44,a Phosphodiesterase 4 Inhibitor,in Osteoblastgenesis and Osteoclastgenesis in Culture and Its Therapeutic Effects in Rat Osteopenia Models

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Abstract

We have reported that denbufylline, a phosphodiesterase 4 (PDE4) inhibitor, inhibits bone loss in Walker256/S tumor-bearing rats, suggesting therapeutic potentiality of a PDE4 inhibitor in osteopenia. In the present study, effects of a new PDE4 inhibitor, 1-n-butyl-3-n-propylxanthine (XT-44), in bone were evaluated in cell cultures and animal experiments. In rat bone marrow culture, XT-44 stimulated mineralized-nodule formation, whereas it inhibited osteoclast-like cell formation in mouse bone marrow culture. In Walker256/S-bearing rats (6-week-old female Wistar Imamichi rats), rapid decrease in bone mineral density (BMD) was prominent, and oral administration of XT-44 (0.3 mg/kg, every 2 days) inhibited the decrease in BMD. In the second animal experiment, female Wistar rats (6-week-old) were sciatic neurectomized, and XT-44 was orally administered to these rats every 2 days for 4 weeks. XT-44 administration (0.3 mg/kg) recovered BMD in these neurectomized animals. Furthermore, 19-week-old, female Wistar rats were ovariectomized (OVX), and 15 weeks after surgery, these rats were orally administered XT-44 every 2 days for 8 weeks. XT-44 treatment (1 mg/kg) increased the BMD of OVX rats. These results indicate that XT-44 could be a candidate as a therapeutic drug for treating osteopenia including osteoporosis.

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