The Protective Effect of Cyclosporine A on Anti-Fas Antibody-Induced Hepatitis in Mice

この論文にアクセスする

この論文をさがす

著者

抄録

The effect of cyclosporine A (CsA) on anti-Fas antibody-induced hepatitis was studied. The administration of anti-Fas antibody (250 μg/kg) to mice elevated plasma alanine aminotransferase (ALT) activity at 3 hr. This anti-Fas antibody-induced elevation of ALT was inhibited by treatment with CsA (10, 30 and 100 mg/kg) in a dose-dependent manner. Anti-Fas antibody administration elevated CPP32-like protease activity at 3 hr in mouse liver, and this elevation of CPP32-like activity was inhibited by treatment with CsA. The present results show that CsA treatment inhibits the anti-Fas antibody-induced apoptotic process of hepatitis, at least in part, by affecting a reaction upstream of CPP32-like protease activation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(4), 485-488, 1999-04-01

    The Japanese Pharmacological Society

参考文献:  10件中 1-10件 を表示

被引用文献:  1件中 1-1件 を表示

キーワード

各種コード

  • NII論文ID(NAID)
    10008683635
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4706179
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ