Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187 : Induced Histamine Release From Rat Peritoneal Exudate Cells

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抄録

The effects of <I>Sasa senanensis</I> Rehder extract (SE) by alkaline hydrolysis on histamine release from rat peritoneal exudate cells (PECs) were examined. Preincubation with SE for 5 min suppressed calcium-ionophore A23187-induced histamine release in a concentration-dependent manner. A23187 evoked a quick increase in cytoplasmic free calcium ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) levels in the presence of extracellular calcium. Preincubation with SE also had an inhibitory effect on calcium influx increases induced by A23187. These results indicate that SE prevents degranulation from rat PECs by inhibiting [Ca<SUP>2+</SUP>]<SUB>i</SUB> level elevation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(4), 489-492, 1999-04-01

    The Japanese Pharmacological Society

参考文献:  13件中 1-13件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008683646
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4706200
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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