Ability of Mosapride to Bind to 5-HT_4 Receptor in the Human Stomach

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Ability of mosapride, a gastrokinetic agent, to bind to 5-HT<SUB>4</SUB> receptor was examined in the stomach of human and guinea pig by in vitro receptor autoradiography. [<SUP>125</SUP>I]SB207710 binding sites were detected in the muscle layer including the myenteric plexus of the stomach from both humans and guinea pigs, although the binding was observed more clearly and densely in the stomach of guinea pigs than humans. Mosapride as well as SB204070 inhibited the binding of [<SUP>125</SUP>I]SB207710. Thus, mosapride possesses the ability to bind to 5-HT<SUB>4</SUB> receptors of human stomach and may modulate the motility, as in the case of guinea pig stomach.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(4), 493-496, 1999-04-01

    The Japanese Pharmacological Society

参考文献:  14件中 1-14件 を表示

被引用文献:  7件中 1-7件 を表示

各種コード

  • NII論文ID(NAID)
    10008683660
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4706225
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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