Studies on the Anxiolytic Activity of Eurycoma longifolia Jack Roots in Mice

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The anxiolytic effect of <I>Eurycoma longifolia</I> Jack in mice was examined. Fractions of <I>E. longifolia</I> Jack extract produced a significant increase in the number of squares crossed (controls=118.2±10.2 squares), but significantly decreased both the immobility (controls=39.4±4.0 sec) and fecal pellets (controls=12.3±2.1 fecal pellets) when compared with control mice in the open-field test; they significantly increased the number of entries (controls=6.7±0.5 entries) and time spent (controls=42.9±0.1 sec) in the open arms, but decreased both the number of entries (controls=13.2±0.7 entries) and time spent (controls=193.4±0.7 sec) when compared with the control mice in the closed arms of the elevated plusmaze test. Furthermore, fractions of <I>E. longifolia</I> Jack extract decreased the fighting episodes significantly (controls=18.0±0.4 fighting episodes) when compared with control mice. In addition, these results were found to be consistent with anxiolytic effect produced by diazepam. Hence, this study supports the medicinal use of this plant for anxiety therapy.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(4), 497-500, 1999-04-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008683675
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4706246
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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