Stimulatory Effects of Centrally Injected Nitric Oxide Donors on Gastric Acid Secretion in Anesthetized Rats.

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  • Tsuchiya Shizuko
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Horie Syunji
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Watanabe Kazuo
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University

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The effects of centrally injected nitric oxide (NO) donors on gastric acid secretion were investigated in continuously perfused stomach of anesthetized rats. The lateral cerebroventricular (LV) injection of NOC5 (30 – 100 μg) and NOC12 (10 – 100 μg) dose-dependently stimulated gastric acid secretion. The LV injection of NOC18 (30 μg) also stimulated gastric acid secretion. The other type of NO donor, sodium nitroprusside (3 – 30 μg, LV), also dose-dependently stimulated gastric acid secretion. The effect of NOC5 at 100 μg was blocked by carboxy-PTIO, an NO scavenger, and by cervical vagotomy. Furthermore, NOC12 (30, 100 μg) dose-dependently stimulated gastric acid secretion in pylorus-ligated conscious rats. These results suggest that centrally injected NO donors stimulate gastric acid secretion in both conscious and anesthetized rats through vagus activation.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 89 (2), 126-132, 2002

    公益社団法人 日本薬理学会

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