Effect of Anti-CD14 Antibody on Experimental Periodontitis Induced by Porphyromonas gingivalis Lipopolysaccharide

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著者

    • KOWASHI Yusuke
    • Department of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido
    • KIKUCHI Masanori
    • National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group
    • SUETSUGU Yasushi
    • National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group
    • TANAKA Junzo
    • National Institute for Materials Science, Advanced Materials Laboratory, Bioceramics Research Group

抄録

The lipopolysaccharide (LPS) released by <i>Porphyromonas gingivalis</i>, a Gram-negative bacterium found in the periodontal pockets of patients with periodontitis, induces bone resorbing activity in vivo. We previously showed that a receptor for LPS on human gingival fibroblasts and gingival epithelial cells is CD14. In this study, we established a mouse model of experimental periodontitis by applying a <i>P. gingivalis</i> LPS solution to the buccal region of mice. <i>P. gingivalis</i> LPS-induced bone resorption and interleukin-6 production in the gingival tissues were significantly inhibited by pretreatment with anti-CD14 antibody for 5 weeks prior to LPS treatment. This result suggests that anti-CD14 antibody may be usable as a prototype for the development of drugs for the treatment of periodontal disease.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 89(2), 176-183, 2002-06-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008684188
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    6262082
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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