Antagonistic Interaction Between BIIE 0246, a Neuropeptide Y Y2-Receptor Antagonist, and ω-Conotoxin GVIA, a Ca2+ Channel Antagonist, in Presynaptic Transmitter Releases in Dog Splenic Arteries

この論文にアクセスする

この論文をさがす

著者

抄録

Isolated dog splenic arteries were perfused with Krebs-Henseleit solution at 37°C, using the cannula inserting method. Periarterial nerve electrical stimulation (10-V amplitude; 1-ms duration; 30-s trains of pulses; 1, 4 and 10 Hz) readily caused double peaked vasoconstrictions, i.e., 1st peaked response was mostly inhibited by α,β-methylene ATP and the 2nd one, by prazosin. These responses were consistently inhibited by ω-conotoxin GVIA (ω-CTX), whereas they were facilitated by BIIE 0246, a neuropeptide Y (NPY) Y<sub>2</sub>-receptor antagonist. The ω-CTX-induced blocking effects of transmitter release were significantly antagonized by BIIE 0246. It is possible that the NPY Y<sub>2</sub> receptor activity may partially be linked to presynaptic Ca<sup>2+</sup> channels.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 89(2), 188-191, 2002-06-01

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10008684237
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    6262132
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ