Antagonistic Interaction Between BIIE 0246, a Neuropeptide Y Y2-Receptor Antagonist, and .OMEGA.-Conotoxin GVIA, a Ca2+ Channel Antagonist, in Presynaptic Transmitter Releases in Dog Splenic Arteries.
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- Yang Xiao-Ping
- Department of Pharmacology, Shinshu University School of Medicine
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- Chiba Shigetoshi
- Department of Pharmacology, Shinshu University School of Medicine
Bibliographic Information
- Other Title
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- Antagonistic Interaction Between BIIE 0246, a Neuropeptide Y Y2-Receptor Antagonist, and ω-Conotoxin GVIA, a Ca2+ Channel Antagonist, in Presynaptic Transmitter Releases in Dog Splenic Arteries
- Antagonistic Interaction Between BIIE 0246 a Neuropeptide Y Y2 Receptor Antagonist and オメガ Conotoxin GVIA a Ca2 Channel Antagonist in Presynaptic Transmitter Releases in Dog Splenic Arteries
- Antagonistic Interaction Between BIIE 0246, a Neuropeptide Y Y2-Receptor Antagonist, and ωy-Conotoxin GVIA, a Ca2+ Channel Antagonist, in Presynaptic Transmitter Releases in Dog Splenic Arteries
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Abstract
Isolated dog splenic arteries were perfused with Krebs-Henseleit solution at 37°C, using the cannula inserting method. Periarterial nerve electrical stimulation (10-V amplitude; 1-ms duration; 30-s trains of pulses; 1, 4 and 10 Hz) readily caused double peaked vasoconstrictions, i.e., 1st peaked response was mostly inhibited by α,β-methylene ATP and the 2nd one, by prazosin. These responses were consistently inhibited by ω-conotoxin GVIA (ω-CTX), whereas they were facilitated by BIIE 0246, a neuropeptide Y (NPY) Y2-receptor antagonist. The ω-CTX-induced blocking effects of transmitter release were significantly antagonized by BIIE 0246. It is possible that the NPY Y2 receptor activity may partially be linked to presynaptic Ca2+ channels.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 89 (2), 188-191, 2002
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204285937024
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- NII Article ID
- 10008684237
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- NII Book ID
- AA00691188
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- COI
- 1:STN:280:DC%2BD38znsFOmtw%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 6262132
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- PubMed
- 12120763
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed