Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

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In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by <i>N</i><sup>G</sup>-nitro-<sc><font size = -2>L</font></sc>-arginine, hexamethonium and methylene blue. <sc><font size = -2>L</font></sc>-Arginine antagonized the <i>N</i><sup>G</sup>-nitro-<sc><font size = -2>L</font></sc>-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 89(2), 197-200, 2002-06-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008684267
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    6262170
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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