ラットｐｏｕｃｈ内混合感染モデルにおける注射用抗菌薬の殺菌効果

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  • Evaluation of bactericidal effect of injectable antibacterial agents in polimicrobial infection using a rat granuloma pouch infection model.

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We studied the bactericidal activity of an injectable quinolone, pazufloxacin (PZFX) mesilate, and injectable β-lactams, ceftazidime (CAZ), and imipenem/cilastatin (IPM/CS) against quinolone-and β-lactam-susceptible Escherichia coli (a non-β-lactamase producer) in mixed infection caused by Enterobacter cloacae H-27 (an inducible β-lactamase producer) and E. coli using a rat pouch infection model, with the following results:<BR>1) The bactericidal activity of IPM/CS against E. coli and its concentration in pouches after intravenous administration of 5 mg/kg to rats with the mixed infection were reduced compared to those in single infection with E. coli. Coexistence of the inducible β-lactamase producer affected IPM/CS activity. CAZ concentrations in pouches in the mixed infection model decreased slightly but its activity was reduced compared to those in single infection with E. coli. The coexistence of the inducible β-lactamase producer also affected CAZ activity. No effects were observed in PZFX mesilate.<BR>2) The bactericidal activity of CAZ against E. coli and its concentration in pouches of rats with the mixed infection and with cefmetazole (CMZ) pretreatment to increase β-lactamase activity in pouches were reduced compared to those in single infection by E. coli and in mixed infection without CMZ pretreatment.β-Lactamase induction affected CAZ activity. IPM/CS bactericidal activity decreased compared to that in single infection by E. coli but was similar to that in mixed infection without CMZ pretreatment.β-Lactamase induction did not affect IPM/CS activity. No effects were observed in PZFX mesilate. Piperacillin pretreatment in place of CMZ did not affect CAZ activity.

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