Prevalence of Serum Anti-Myeloperoxidase Antineutrophil Cytoplasmic Antibodies (MPO-ANCA) in Patients with Graves' Disease Treated with Propyithiouracil and Thiamazole

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著者

    • WADA Norio
    • Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital
    • MUKAI Masaya
    • Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital
    • KOHNO Michifumi
    • Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital
    • NOTOYA Atsushi
    • Division of Immunology and Hematology, Department of Medicine, Sapporo City General Hospital
    • ITO Tomohiro
    • Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital
    • YOSHIOKA Narihito
    • Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital

抄録

Patients with Graves' disease (n=61) treated wth propylthiouracil (PTU) or thiamazole (MMI) were studied retrospectively to investigate differences in the prevalence of anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) in relation to treatment with anti-thyroid drugs. The patients were divided into two groups: PTU-treated group (n=32) and MMI-treated group (n=29). There were no significant differences between the two groups in terms of age, gender distribution, or duration of treatment. In the PTU group, 8/32 (25%) patients were positive for MPO-ANCA, whereas in the MMI group, 1/29 (3.4%) patients were positive. There were no significant differences in age, duration, or dosage between the MPO-ANCA positive and negative patients. Most of the MPO-ANCA positive patients were asymptomatic, except for two patients in whom rheumatic arthritis or membranous glomerulonephritis developed. None of the MPO-ANCA positive patients were diagnosed as having classical ANCA-associated vasculitis. Thus, there is a high frequency of MPO-ANCA in patients with Graves' disease treated with PTU, compared with patients treated with MMI, although classical ANCA-associated vasculitis develops in only a few MPO-ANCA positive patients.

収録刊行物

  • Endocrine journal

    Endocrine journal 49(3), 329-334, 2002-06-01

    The Japan Endocrine Society

参考文献:  32件中 1-32件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008701528
  • NII書誌ID(NCID)
    AA10901436
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09188959
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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