The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells

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著者

    • HONMA Susumu
    • Department of Obstetrics and Gynecology, Showa University School of Medicine
    • SHIMIZU Yukiko
    • Department of Obstetrics and Gynecology, Showa University School of Medicine
    • TSUCHIYA Naoko
    • Department of Obstetrics and Gynecology, Showa University School of Medicine
    • SAITO Hiroshi
    • Department of Obstetrics and Gynecology, Showa University School of Medicine
    • YANAIHARA Takumi
    • Department of Obstetrics and Gynecology, Showa University School of Medicine
    • OKAI Takashi
    • Department of Obstetrics and Gynecology, Showa University School of Medicine

抄録

Estrogens play important roles in the development of breast cancer. Inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-1β (IL-1β) exist at high concentrations in breast cancer tissue. Although these cytokines are thought to exert some effect on cancer growth, their precise mechanism is still unclear. In the present study, we investigated the effects of inflammatory cytokines on aromatase (Arom) and steroid sulfatase (STS), which are estrogen-producing enzymes, and cell proliferation using human breast cancer cell lines (SK-BR-3, MCF-7). IL-6 and IL-1β stimulated the activity of Arom and STS. Estrone sulfate (E<sub>1</sub>-S) had a stimulus effect on cell proliferation of MCF-7. Although IL-6 did not show significant effect on cell proliferation, cell proliferation was significantly increased when IL-6 and E<sub>1</sub>-S were simultaneously added to the incubation medium. This cell proliferative effect was apparently stronger than the addition of E<sub>1</sub>-S alone. Addition of IL-1β in the presence of E<sub>1</sub>-S also significantly enhanced cell proliferation though IL-1β alone did not show any effect. These results led us to the hypothesis that inflammatory cytokines such as IL-6 and IL-1β regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue.

収録刊行物

  • Endocrine journal

    Endocrine journal 49(3), 371-377, 2002-06-01

    The Japan Endocrine Society

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各種コード

  • NII論文ID(NAID)
    10008701715
  • NII書誌ID(NCID)
    AA10901436
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09188959
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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