The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells.

• HONMA SUSUMU

  Department of Obstetrics and Gynecology, Showa University School of Medicine

• SHIMODAIRA KAZUHISA

  Department of Obstetrics and Gynecology, Showa University School of Medicine

• SHIMIZU YUKIKO

  Department of Obstetrics and Gynecology, Showa University School of Medicine

• TSUCHIYA NAOKO

  Department of Obstetrics and Gynecology, Showa University School of Medicine

• SAITO HIROSHI

  Department of Obstetrics and Gynecology, Showa University School of Medicine

• YANAIHARA TAKUMI

  Department of Obstetrics and Gynecology, Showa University School of Medicine

• OKAI TAKASHI

  Department of Obstetrics and Gynecology, Showa University School of Medicine

抄録

Estrogens play important roles in the development of breast cancer. Inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-1β (IL-1β) exist at high concentrations in breast cancer tissue. Although these cytokines are thought to exert some effect on cancer growth, their precise mechanism is still unclear. In the present study, we investigated the effects of inflammatory cytokines on aromatase (Arom) and steroid sulfatase (STS), which are estrogen-producing enzymes, and cell proliferation using human breast cancer cell lines (SK-BR-3, MCF-7). IL-6 and IL-1β stimulated the activity of Arom and STS. Estrone sulfate (E₁-S) had a stimulus effect on cell proliferation of MCF-7. Although IL-6 did not show significant effect on cell proliferation, cell proliferation was significantly increased when IL-6 and E₁-S were simultaneously added to the incubation medium. This cell proliferative effect was apparently stronger than the addition of E₁-S alone. Addition of IL-1β in the presence of E₁-S also significantly enhanced cell proliferation though IL-1β alone did not show any effect. These results led us to the hypothesis that inflammatory cytokines such as IL-6 and IL-1β regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue.

収録刊行物

• Endocrine Journal

  Endocrine Journal 49 (3), 371-377, 2002

  一般社団法人 日本内分泌学会

キーワード

• Human breast cancer
• Estrogen
• Estrogen producing enzymes
• Inflammatory cytokines

詳細情報

• CRID: 1390001206300167040
• NII論文ID: 10008701715
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.49.371
• COI: 1:CAS:528:DC%2BD38XntVeru7w%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 12201223
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/49/3/49_3_371/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002278033
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
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