Clinical Significance of Eosinophilic Cationic Protein in Serum and Bronchoalveolar Lavage Fluid of Adult Patients with Mycoplasmal Pneumonia

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  • 成人マイコプラズマ肺炎における血清およびBALF中のECPの臨床的意義
  • セイジン マイコプラズマ ハイエン ニ オケル ケッセイ オヨビ BALF チュウ ノ ECP ノ リンショウテキ イギ

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Abstract

Pathogenic mechanisms of mycoplasmal pneumonia is not fully understood at present though some kind of cell-mediated hypersensitivity is closely related to its mechanisms. Though eosinophilia in peripheral blood are sometimes revealed in patient with mycoplasmal pneumonia, it is not unclear whether eosinophils related to its pathogenesis, or not. We evaluated the clinical significance of ECP in serum and BAL fluid in patients with mycoplasmal pneumonia. The diagnosis of mycoplasmal pneumonia was confirmed both by serological diagnosis from paired serum and by the polymerase chain reaction (PCR) methods using specific primers of the Mycoplasma pneumoniae for detecting specific DNA from bronchial washing fluids. ECP level in serum were measured in 27 patients (11 male, 16 female, average age 31.7yo) with mycoplasmal pneumonia by ELISA methods. ECP level in BALF were also measured in ten of all patients. The level of ECP in serum was high in 17 cases (63%) of the total cases. In addition the level of ECP in BALF was also high in all tested patients (10 cases). There was a correlation between serum ECP level and days from onset. There was also a correlation between serum ECP level and WBC counts, the degree of Pa02. These results suggested that ECP derived from activated eosinophils in the lung might in part play a role in the pathogenesis of mycoplasmal pneumonia.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 75 (1), 36-41, 2001

    The Japanese Association for Infectious Diseases

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