A Trial of Amantadine for the Treatment of Influenza A Infection in Children

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  • A型インフルエンザ流行期の小児における塩酸アマンタジンの使用経験
  • Aガタ インフルエンザ リュウコウキ ノ ショウニ ニ オケル エンサン アマンタジン ノ シヨウ ケイケン

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Abstract

We administered amantadine to 52 children for therapy and 3 children for prophylaxis of influenza A infection from January to March 1998. Among the 23 children in the therapy group withproven influenza A/H3N2 infection, 15 patients (60%) allayed fever within 3 days but 9 (40%) hadpersistent fever for more than 4 days after administration of amantadine. Seven of these nine patients (40%) received amantadine within 2 days after the onset of fever. Two of these nine had secondarybacterial infections. One child had insomnia as side effect. We concluded that administrationof amantadine for therapy is safe and effective, if given to patients without secondary bacterial infections in the first 48 hours of the illness.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 74 (1), 6-11, 2000

    The Japanese Association for Infectious Diseases

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