Antibody Induction and Frequency of Adverse Reactions to Influenza Vaccines in the Elderly

• MURAYAMA Naoya

  Department of Public Health, Niigata University School of Medicine The 2nd Department of Internal Medicine, Niigata University School of Medicine

• SAITO Reiko

  Department of Public Health, Niigata University School of Medicine

• SUZUKI Hiroshi

  Department of Public Health, Niigata University School of Medicine

• OSHITANI Hitoshi

  Department of Public Health, Niigata University School of Medicine

• KAWASAKI Satoshi

  Department of Public Health, Niigata University School of Medicine The 2nd Department of Internal Medicine, Niigata University School of Medicine

• NISHIKAWA Makoto

  Niigata Prefectiural Research Laboratory for Health and Environment

• ARAKAWA Masaaki

  The 2nd Department of Internal Medicine, Niigata University School of Medicine

Bibliographic Information

Other Title

• 高齢者におけるインフルエンザワクチン接種後の抗体変動と副反応
• コウレイシャ ニ オケル インフルエンザワクチン セッシュ ゴ ノ コウタイ ヘンドウ ト フクハンノウ

Abstract

A total of 1, 223 elderly people in nursing homes in Niigata Prefecture, Japan, were immunizedwith one or two doses of commercial trivalent split vaccine formulation, against strains including A/HN, A/H3N2 and B for three seasons (1996-1999). The frequencies of adverse reactions and antibodyinduction were assessed.<BR>Frequent side effects of vaccination were local reactions such as redness and tennerness at thesite of injection, but there were no serious reactions, suggesting that the vaccine was quite safe forthe elderly. Furthermore, antibody induction by immunization was relatively high and independentof the degree of activities of daily living (ADL). Annual repeated influenza vaccination did not diminishprotection against influenza. However, antibody induction against antigens was insufficient in the1997/1998 season, and further improvement in the combination of quantities of the four included antigensmay by required. A booster dose after the first dose did not enhance immune responses in the nursing staff, and the one dose method appeared to be indicated for the elderly.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 74 (1), 30-36, 2000

  The Japanese Association for Infectious Diseases

Keywords

• influenza vaccine
• immunization
• antibody response
• side effect
• elderly

Details

• CRID: 1390282680026919168
• NII Article ID: 130004112716
• NII Article ID: 10008978801
• NII Article ID: 10008704435
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.74.30
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 4974530
• PubMed: 10695292
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4974530
• Web Site: https://search.jamas.or.jp/link/ui/2000141511
• Data Source:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed