Interferon-Induced Vertigo. A Clinical Study of 2 Patients.

DOI 7 References
  • Osanai Ryuichi
    Department of Otolaryngology, Saitama Medical Center, Saitama Medical School
  • Kawabata Isuzu
    Department of Otolaryngology, Saitama Medical Center, Saitama Medical School

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Other Title
  • インターフェロン療法中に発症しためまいの２症例

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Abstract

Neurotological findings of two patients with chronic hepatitis C who developed ver-tigo after interferon therapy are described. The patients were a 62-year-old male who developed dizziness after intramuscular injections of interferon-α and a 55-year-old female who developed positional vertigo after intramuscular injections of interferon-α-2a. Down-beating positional nystagmus was observed in the supine and the supine head-down positions in both patients, but no gaze nystagmus or spontaneous nystagmus was noted. Signs and symptoms were relieved after reduction of the dose of interferon. Elec-tro-nystagmographic (ENG) studies were performed before and after an injection of in-terferon in the female patient. She exhibited hypermetric saccades and increased size of the down-beating positional nystagmus in ENG recorded 6 hours after the interferon in-jection. Several pathophysiological hypotheses about interferon-induced vertigo, in-cluding direct effects of interferon on the central nervous system, are discussed, but they are still to be proved by basic and clinical studies.

Journal

  • Equilibrium Research

    Equilibrium Research 54 (2), 202-207, 1995

    Japan Society for Equilibrium Research

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