視性訓練による視性平衡機能向上の研究（２）　ＮＭＤＡ受容体の役割

• 青木 光広

  岐阜大学医学部耳鼻咽喉科学教室

• 宮田 英雄

  岐阜大学医学部耳鼻咽喉科学教室

• 水田 啓介

  岐阜大学医学部耳鼻咽喉科学教室

• 伊藤 八次

  岐阜大学医学部耳鼻咽喉科学教室

書誌事項

タイトル別名

• Improvement of Optokinetic Reflexes by Optokinetic Training (2). Role of NMDA Receptors.
• Role of NMDA Recepators
• NMDA受容体の役割

抄録

To evaluate the involvement of N-methyl-D-aspartic acid (NMDA) receptors in the optokinetic training (OKT)-induced improvement of optokinetic nystagmus (OKN), we examined the effect on the optokinetic reflex of MK-801 ((±)-5-metyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5, 10-imine maleate). Experiments were performed on pigmented rabbits in which OKN had been improved by OKT for 12 days. When MK-801 was injected intramuscularly, OKN was blocked; this blockade was completely reversed within 72 hrs. At non-intoxic doses (0.05 and 0.1 mg/kg), this drug caused an in-crease in locomotor activity and a reduction of OKN. On the other hand, neither the postrotatory nystagmus (PRN) nor the electroencephalogram (EEG) of the cerebral neocortex and hippocampus was influenced by non-intoxic doses of MK-801. A similar effect was observed on both atropine-sensitive and atropine-resistant EEGs. These results indicate that MK-801-induced impairment of OKN is probably due to its inhibition of NMDA receptors in the oculomotor pathway, suggesting that the activation of this recep-tor may be involved in the improvement of OKN by OKT.

収録刊行物

• Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ

  Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ 54 (3), 287-295, 1995

  一般社団法人 日本めまい平衡医学会

キーワード

• optokinetic training
• optokinetic nystagmus
• MK-801
• NMDA receptors
• oculomotor pathway

詳細情報

• CRID: 1390001204945208192
• NII論文ID: 10008707884
• NII書誌ID: AN00001485
• DOI: 10.3757/jser.54.287
• ISSN: 1882577X
• ISSN: 03855716
• Web Site: https://search.jamas.or.jp/link/ui/1996033670
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可