血管迷走神経反射におけるアドレナリンの脳血流に及ぼす影響 : ネコを使用した血管迷走神経反射の実験的モデル Effect of Adrenaline on Cerebral Blood Flow during Vasovagal Reflex : An Experimental Cat Model of Vasovagal Reflex

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Introduction<BR>The vasovagal reflex causes spontaneous dizziness which appears in a standing or sitting position. This reaction is probably caused by the autonomic reflex. It has long been recognized that the plasma adrenaline (Adr.) level elevates during vasovagal attacks. However, the effect of Adr. on cerebral blood flow during vasovagal reflex has not yet been clarified.<BR>Purpose<BR>This study investigated the effect of Adr. on cerebral blood flow during vasovagal reflex in an experimental cat model.<BR>Methods<BR>Ten cats were tracheotomized and restrained in the supine position with its head raised at a 30-degree angle. Upon vagal neurotomy, the nerve fiber on the cardiac side was subjected to electrostimulation for 1 minute. Intravenous Adr. was infused at 0.25 μg/kg for 30 seconds. The regional blood flows in the nucleus vestibularis, nucleus olivaris inferior and nucleus fastigii were measured by the hydrogen clearance method. Changes in heart rate, blood pressure, and regional blood flow were compared among the three groups; Adr. injection alone (Adr. group), electrostimulation alone (electrostimulation group), and Adr. injection+electrostimulation (Adr.+electrostimulation group).<BR>Results<BR>Heart rate and blood pressure increased in the Adr. group (p<0.01), decreased significantly in the electrostimulation group (p<0.01), whereas there were no changes in the Adr. +electrostimulation group. Blood flows increased in the Adr. group (p<0.01), and decreased in electrostimulation and Adr.+electrostimulation groups (p<0.01). However, there was a more significant decrease in the Adr.+electrostimulation group than in the electrostimulation group (nucleus vestibularis: -3.5 vs. -3.9 ml/min/100 g, p<0.01, nucleus olivaris inferior: -9.4 vs. -2.5 ml/min/100 g, p<0.01, and nucleus fastigii: -7.8 vs. -2.8 ml/min/100 g, p<0.01).<BR>Conclusions<BR>Although Adr. increased cerebral blood flow, Adr. combined with vagal stimulation reduced blood flow more than vagal stimulation alone. This could be explained by accentuated antagonism.

収録刊行物

  • Equilibrium research

    Equilibrium research 57(5), 529-535, 1998-10-01

    Japan Society for Equilibrium Research

参考文献:  19件中 1-19件 を表示

被引用文献:  7件中 1-7件 を表示

各種コード

  • NII論文ID(NAID)
    10008711575
  • NII書誌ID(NCID)
    AN00001485
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03855716
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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