A Two-year Follow-up of Zidovudine Plus Lamivudine Combined with Indinavir in Antivival Naive HIV-infected Patients

DOI Web Site PubMed 13 References

Bibliographic Information

Other Title
  • 抗HIV無治療患者に対するZidovudine/Lamivudine/Indinavir併用療法の2年間の治療経過
  • コウHIV ムチリョウ カンジャ ニ タイスル Zidovudine Lamivudine Indinavir ヘイヨウ リョウホウ ノ 2ネンカン ノ チリョウ ケイカ

Search this article

Abstract

Efficacy of a 3-drug combination (Zidovudine (AZT) +Lamivudine (3TC) +Indinavir (IDV)) has been evaluated in 17 anti-viral naive patients with HIV infection for 24 months. Our genotypic resistance assay was able to analyze more than 80% of the patients whose viral load (VL) was over 3, 000 copies/ml. This therapy was continued in 11 patients (65%) for 24 months. Among them, VL was undetectable (VI<400copies/ml) in patients at 24 month (47% by intent-to-treat, 72% by on treatment). Of the 11 patients, a 3TC resistance-related mutantion was detected in only one case. The therapy was discontinued in 6 cases. Main reasons of the discontinuation were side effects. However, if the therapy was switched to other combinations when VL was undetectable, VL remained undetectable in 5 cases at 24 month.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 74 (2), 128-133, 2000

    The Japanese Association for Infectious Diseases

References(13)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top