Serum Concentration of Amantadine in the Treatment of Children with Influenza Type A Infection

• KIMURA Kazuhiro

  Denartment of Pediatrics, Isehara Kyodo Hospital

• KOMIYAMA Osamu

  Denartment of Pediatrics, Isehara Kyodo Hospital

• YAMAZAKI Masahiko

  Denartment of Pediatrics, Isehara Kyodo Hospital

• YAMAMOTO Keiichi

  Denartment of Pediatrics, Isehara Kyodo Hospital

• SUGAYA Norio

  Departrent of Pediatrics, Nippon Kokan Hospital

Bibliographic Information

Other Title

• 小児のA型インフルエンザ感染症治療でのアマンタジン血清濃度
• ショウニ ノ Aガタ インフルエンザ カンセンショウ チリョウ デ ノ アマンタジン ケッセイ ノウド

Abstract

Fifteen children with influenza type A (H3N2) virus infection (mean age, 38 mosths) were treated with amantadine. Amantadine was prescribed as 5 mg/kg/day and the serum concentration was measured in 5-7 days. As a result, the mean serum concentration of amantadine was 164.6-92.5ng/ml (range, 67.4-446.9ng/ml). Adverse reactions were not associated to them. Amantadine therapy against influenza type A infection is probably safe in children because of the low serum concentration shown in this study.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 74 (9), 699-702, 2000

  The Japanese Association for Infectious Diseases

Keywords

• influenza
• amantadine
• children

Details

• CRID: 1390282680025783168
• NII Article ID: 130004330910
• NII Article ID: 10008713426
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.74.699
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 5503888
• PubMed: 11068362
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5503888
• Web Site: https://search.jamas.or.jp/link/ui/2001048699
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed