Successful Treatment of Primary CNS Lymphoma Diagnosed by <SUP>201</SUP>Thallium-single Photon Emission Computed Tomography (<SUP>201</SUP>Tl-SPECT) with Whole-brain Radiation Therapy in an AIDS Patient

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  • OKUBO Tadanobu
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • IHATA Atsushi
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • NAKAMURA Mitsuyuki
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • UEDA Atsuhisa
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • OHNO Shigeru
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • HAGIWARA Eri
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • SHIRAI Akira
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • KANAMORI Heiwa
    The First Department of Internal Medicine, Yokohama City University School of Medicine
  • ISHIGATSUBO Yoshiaki
    The First Department of Internal Medicine, Yokohama City University School of Medicine

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Other Title
  • トキソプラズマ脳症との鑑別に<SUP>201</SUP>Thallium-single photon emission computed tomography (<SUP>201</SUP>Tl-SPECT) が有効であった脳原発悪性リンパ腫を合併したAIDS症例
  • Successful Treatment of Primary CNS Lymphoma Diagnosed by 201Thallium-single Photon Emission Computed Tomography (201Tl-SPECT) with Whole-brain Radiation Therapy in an AIDS Patient

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Abstract

The patient, a 51-year-old male with a two year history of AIDS, was admitted to our hospital because of hemiparalysis and vomiting. The MRI study showed multiple lesions with ring-enhancement in the right basal brain area. Empirical therapy for toxoplasma encephalitis was started. After 64 days, the subsequent brain MRI showed deterioration. A 201T1-SPECT study was performed and the findings were consistent with those of malignant lymphoma (ML). The patient was treated with 40 Gy of whole brain radiation, MRI showed partial response to this therapy, and clinical improvement was achieved. The definitive diagnosis of primary CNS lymphoma can be made only by brain biopsy, and many cases have been diagnosed at autopsy. The clinical and radiological findings of primary CNS lymphoma resemble toxoplasma encephalitis. An empirical therapyfor toxoplasma encephalitis is recommended to avoid brain biopsy in these cases. The use of 201Tl-SPECT for the differential diagnosis of these diseases have been reported. Considering the poor prognosis of primary CNS lymphoma in AIDS, the application of 201Tl-SPECT before empirical therapy for toxoplasma must be important for appropriate treatment.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 73 (6), 609-613, 1999

    The Japanese Association for Infectious Diseases

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