A Case of Influenza A Virus Associated Encephalopathy with Bilateral Thalamic Hemorrhage
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- SHINJOH Masayoshi
- Department of Virology L National Institute of Infectious Diseases
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- SUGAYA Norio
- Department of Pediatrics Nippon Kokan Hospital
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- TAKAHASHI Eisuke
- Department of pediatrics Hiratsuka Kyosai Hospital
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- YONEYAMA Hiroshi
- Department of pediatrics Hiratsuka Kyosai Hospital
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- JOZAKI Keiji
- Department of pediatrics Hiratsuka Kyosai Hospital
Bibliographic Information
- Other Title
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- 両側視床出血を呈したA型インフルエンザ脳症の1例
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Abstract
A three-year old girl was hospitalized in a semi-conscious state following a febrile convulsion. She did not recover despite treatment and died 16 days after admission. Influenza A virus (H3N2) was detected from a throat swab from the patient, and serum hemagglutinin-inhibiting antibodies to the virus elevated from less than 8 to 256. Brain CT revealed bilateral thalamic hemorrhage and peripheral low density. Subarachnoid hemorrhage was also observed thereafter. Based on clinical manifestations and neuroimaging, this patient was diagnosed as an atypical case of acute necrotizing encephalopathy associated with influenza A virus infection. Such rapid progressive encephalopathies may occur due to intracranial vascular injury including vasculitis or spasms. Although it is clear that influenza A virus triggered this case, we cannot confirm that it was a pathogen. Also, it might be advisable to consider other possible contributing factors such as drugs administered before hospitalization.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 73 (8), 778-782, 1999
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390001205048983424
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- NII Article ID
- 130004330802
- 10008716317
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- PubMed
- 10487024
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed