Difference of Host Response in Identical Toxin-produced <I>Staphylococcus aureus</I>-injected Mice

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  • ONOGAWA Tsuyoshi
    Department of Immunology, School of Health Sciences, Kyorin University
  • ENDO Nobuko
    Department of Immunology, School of Health Sciences, Kyorin University

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Other Title
  • 毒素産生黄色ブドウ球菌の接種マウスにおける致死活性と生体反応の比較
  • ドクソ サンセイ オウショクブドウキュウキン ノ セッシュ マウス ニ オケル
  • Difference of Host Response in Identical Toxin-produced Staphylococcus aureus-injected Mice

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Abstract

Biological activities of two strains of Staphylococcus aureus (S. aureus), KU-1-06-37 and KU-1-12-44, which produce enterotoxin type C, TSST-1 and α-toxin were examined using Std: ddY strain mice. These two strains were found to be different in lethality, ratio of weight loss, induction of leukopenia, adhesion to surrounding organs and clearance period of bacterial cells from the liver, kidney and spleen within 24 hrs after intraperitoneal injection in the mice. All of them were weak or fast in KU-1-12-44 injected mice. Serum amyloid A on all the KU-1-06-37 and KU-1-12-44 injected mice rose within 5 hr to 18 hr. However, this concentration of KU-1-12-44 injected mice was about 40% lower compared with that of KU-1-06-37 injected mice at 21 hr. On the other hand, ability of bacterial adhesion to established cell lines, Vero and HeLa cells, was tested in vitro. Percentage adhesion of KU-1-06-37 was high to both cells, but that of KU-1-12-44 was high to Vero cells and was low to HeLa cells. Adhesion of KU-1-06-37 to HeLa cells that were treated with lipoteichoic acid was about 40% inhibition compared with untreated cells, although that of KU-1-12-44 to them was inhibited only 9%. As the results, identical toxinproduced KU-1-06-37 and KU-1-12-44 showed different biological activities in vivo and in vitro. Not only toxin production but also adhesion to cells or organs in mice may contribute to S. aureus virulence to the host.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 72 (5), 536-542, 1998

    The Japanese Association for Infectious Diseases

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