Suppressive Effect of Clarithromycin on the Production of Verotoxin by <I>E. coli</I>O157

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  • NAKATA Koh
    Laboratory of Culture Collection, The Institute of Medical Science, The University of Tokyo
  • TOZU Tokie
    Laboratory of Culture Collection, The Institute of Medical Science, The University of Tokyo
  • HOSHIKAWA Yuki
    Laboratory of Culture Collection, The Institute of Medical Science, The University of Tokyo
  • SAKAI Atsuko
    Laboratory of Culture Collection, The Institute of Medical Science, The University of Tokyo
  • TANAKA Naohiko
    Laboratory of Culture Collection, The Institute of Medical Science, The University of Tokyo Department of Medicine, School of Medicine, Kitasato University
  • AKASHI Toshi
    Medical Research Laboratories, Taisho Pharmaceutical CO., LTD.
  • KANEGASAKI Shiro
    Laboratory of Culture Collection, The Institute of Medical Science, The University of Tokyo

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Other Title
  • 病原性大腸菌O157のVero毒素産生に対するクラリスロマイシンの抑制効果
  • ビョウゲンセイ ダイチョウキン O157 ノ Vero ドクソ サンセイ ニ
  • Suppressive Effect of Clarithromycin on the Production of Verotoxin by E. coliO157

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Abstract

Effects of low concentration of clarithromycin (CAM) on the production of Verotoxin (VT) by Escherichia coli O157 was investigated in vitro. The production of VT1 was suppressed up to 10 hours when bacteria was incubated with 0.64μg/ml (equivalent to the 1/100th of MIC) or higher concentrations. However, the production of VT1 reached to the control level after 22 hours even with 6.4μg/ml of CAM. On the other hand, production of VT2 by 22 hours was partially suppressed with 0.64μg/ml of CAM and completely with 6.4μg/ml of CAM. When the eight clinical isolates were incubated with 0.64 or 6.4μg/ml of CAM, VT1 and VT2 were suppressed in two and eight strains, respectively. In these strains, similar but less effiicinet suppression of the toxin production was also observed with erythromycin. In contrast to the macrorides, ampicilin did not inhibit or rather stimulated the production of VT1 and VT2 in some strains.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 71 (5), 437-442, 1997

    The Japanese Association for Infectious Diseases

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