Evaluation of Interferon Treatment in Cirrhotic Patients with Hepatitis C
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- IDE Tatsuya
- The Second Department of Internal Medicine, Kurume University School of Medicine
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- SATA Michio
- The Second Department of Internal Medicine, Kurume University School of Medicine
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- SUZUKI Hiroshi
- The Second Department of Internal Medicine, Kurume University School of Medicine
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- MURASHIMA Shiroh
- The Second Department of Internal Medicine, Kurume University School of Medicine
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- MIYAJIMA Ichiroh
- The Second Department of Internal Medicine, Kurume University School of Medicine
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- SHIRACHI Miki
- The Second Department of Internal Medicine, Kurume University School of Medicine
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- TANIKAWA Kyuichi
- The Second Department of Internal Medicine, Kurume University School of Medicine
Bibliographic Information
- Other Title
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- C型肝硬変患者におけるインターフェロンの治療効果
- Evaluation of Interferon Treatment in C
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Abstract
The aim of this study was to examine the effects of interferon on cirrhotic patients with hepatitis C and the incidence of adverse reactions.<BR>The subjects were 35 cirrhotic patients, and 29 chronic active hepatitis patients without cirrhosis (CAH) served as controls. The cirrhotic patients received 3 or 6 million units of human lymphoblastoid interferon daily for one or two weeks and then three times a week for 22 or 23 weeks, while the CAH patients received 6 million units daily for 2 weeks and then three times a week for 14 or 16 weeks. Discontinuation of interferon treatment or dose reduction was required in the 7 cirrhotic patients. The most frequent reason was thrombocytopenia. Dose reduction alone was necessary in two CAH patients. Five cirrhotic patients (14.3%) and nine CAH patients (31.0%) were classified as complete responders to interferon treatment. In all five complete responders with cirrhosis, the hepatitis C virus RNA level before treatment was less than 5 log copies/50μl. The results of this study confirm the beneficial effect of interferon in selected patients with cirrhosis on basis of pre-treatment virus levels and platelet count.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 70 (6), 597-604, 1996
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390282680022765056
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- NII Article ID
- 130004112544
- 10008723290
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 3987624
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- PubMed
- 8741709
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed