Sequential Interferon-α and β Treatment in Patients with Chronic Hepatitis C

• MIYAJIMA Ichiro

  Second Department of Medicine, Kurume University School of Medicine

• SATA Michio

  Second Department of Medicine, Kurume University School of Medicine

• UCHIMURA Yasuyo

  Second Department of Medicine, Kurume University School of Medicine

• IDE Tatsuya

  Second Department of Medicine, Kurume University School of Medicine

• SUZUKI Hiroshi

  Second Department of Medicine, Kurume University School of Medicine

• TANIKAWA Kyuichi

  Second Department of Medicine, Kurume University School of Medicine

Bibliographic Information

Other Title

• C型慢性肝炎患者に対するIFN-α, βの併用療法
• Sequential Interferon アルファ and ベータ Trea
• Sequential Interferon-^|^alpha; and ^|^beta; Treatment in Patients with Chronic Hepatitis C

Abstract

To assess the effectiveness and side effects of sequential interferon (IFN)-α and β treatment for patients with chronic hepatitis C, 25 patients were enrolled in a trial of this regimen. The patients were given 6 million units (MU) of natural human INF-β daily for 2 weeks followed by 6 MU of natural human IFN-α three times a week for 10 to 22 weeks. Serum alanine aminotransferase (ALT) levels normalized for at least 24 weeks in 10 patients (40%), of whom 4 (40%) had no detectable serum hepatitis C virus (HCV) RNA. Three variables were significant in predicting a sustained response: a low serum HCV RNA level, a low Knodell's fibrosis score, and a low indocyanine green retention rate at 15 minutes. Elevated serum ALT and proteinurea were observed with IFN-β treatment but these side effects were mild and disappeared when INF-β treatment ended. While all patients completed the entire regimen, we concluded that sequential IFN-α and β treatment provides no additional antiviral effects in chronic hepatitis C.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 70 (7), 690-695, 1996

  The Japanese Association for Infectious Diseases

Keywords

• interferon-α
• interferon-β
• chronic hepatitis C

Details

• CRID: 1390282680023281280
• NII Article ID: 130004330478
• NII Article ID: 10008723465
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.70.690
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 4005885
• PubMed: 8797303
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4005885
• Web Site: https://search.jamas.or.jp/link/ui/1997003630
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed