A Study of Relapsed Cases of Vivax Malaria after the Standard Primaquine Therapy

• KIMURA Mikio

  Department of Infectious Diseases & Applied Immunology, Institute of Medical Science, University of Tokyo

• TOMIZAWA Isao

  Department of Infectious Diseases, Minamigaoka Branch, Sapporo City General Hospital

• TAKIZAWA Yoshihiko

  Department of Infectious Diseases, Minamigaoka Branch, Sapporo City General Hospital

• OHTOMO Hiroshi

  Department of Tropical Medicine, Jikei University School of Medicine

Bibliographic Information

Other Title

• 三日熱マラリアにおけるプリマキン標準療法後の再発例の検討
• ミッカ ネツ マラリア ニ オケル プリマキン ヒョウジュン リョウホウゴ ノ

Abstract

Vivax malaria is the most frequent among imported malaria in Japan, comprising about 60% of the total cases. Usually, after the acute phase therapy, e.g. with chloroquine, patients with vivax malaria are treated with the standard course of primaquine, i.e. 15 mg base/day for 14 days, as curative therapy. Recently, however, cases of relapse of vivax malaria after this standard primaquine therapy were reported from various countries and were also encountered in Japan. This report showed that the relapse after the standard primaquine therapy occurred most frequently in the cases acquired in Papua New Guinea, followed by Indonesia and Thailand. In contrast, the relapse rate of the cases acquired in India was low.<BR>Most of the relapsed cases were successfully treated with either of the regimens 1) 30 mg/day for 7 days, 2) 2 courses of the standard primaquine therapy given 1 month apart or 3) 15 mg/day for 21 days, without noticeable side effects.<BR>It is imperative to establish the most appropriate regimen with primaquine for the curative treatment of vivax malaria contracted in the areas mentioned above.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 70 (10), 1086-1091, 1996

  The Japanese Association for Infectious Diseases

Keywords

• vivax malaria
• primaquine
• relapse
• drug resistance

Details

• CRID: 1390001205044143872
• NII Article ID: 130004330419
• NII Article ID: 10008723988
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.70.1086
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 4069574
• PubMed: 8952270
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4069574
• Web Site: https://search.jamas.or.jp/link/ui/1997064499
• Data Source:
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  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed