かくたんにおける抗酸菌塗まつ陽性培養陰性　　抗酸菌検出における諸問題に関連して

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タイトル別名
  • THE SMEAR-POSITIVE AND CULTURE-NEGATIVE PHENOMENON OF MYCOBACTERIA IN SPUTUM SPECIMENS IN RELATION TO THE PROBLEMS ON THE DETECTION OF MYCOBACTERIA
  • カクタン ニ オケル コウサンキン トマツ ヨウセイ バイヨウ インセイ コウ
  • 抗酸菌検出における諸問題に関連して

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抄録

It is estimated that the number of sputum smear-positive and culture-negative cases (SPCN) has recently been increasing in Japan.<BR>Although this phenomenon has been well known since the early stage of tuberculosis chemotherapy era, its clinical significance is as yet not so clear<BR>From the review of literatures and based on the author's own experiences, it may be summarized as follows:<BR>Some of this phenomenon are caused by technical errors during the procedure of staining or microscopical examination.<BR>The routine culture method widely employed at present is reliable enough for clinical purpose, if it is performed very carefully; for example, the immediate inoculation after alkali treatment, reduced inoculum size and stable temperature during incubation.<BR>The incubation period of all SPCN specimens should be extended up to sixteen weeks.<BR>The SPCN cases found during the course of primary chemotherapy with intensive regimens are regarded as a normal step prior to negative conversion of bacilli both on smear and culture, in spite of the possible growth in extended incubation period.<BR>The phenomen of repeated SPCN was found mainly in patients treated with long-term chemotherapy. If colonies grow during the extended incubation in such a case, a risk of deterioration in the future is high and the prognosis is not favourable.<BR>Briefly, it may be concluded that the SPCN cases have no clinical significance, if there is no growth during the extended incubation period.

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  • 結核

    結核 56 (6), 291-299, 1981

    一般社団法人 日本結核病学会

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