Dopaminergic Modulation of Physiological and Pathological Neurohumoral Activation in Man

• Smit Andries J.

  Department of Medicine, University Hospital Groningen Department of Cardiology, University Hospital Groningen

• Lieverse Aloysius G.

  Department of Medicine, University Hospital Groningen

• Veldhuisen Dirk Jan van

  Department of Cardiology, University Hospital Groningen

• Girbes Armand R.J.

  Division of Intensive Care, the Department of Surgery, University Hospital Groningen

抄録

Close relations exist between the peripheral dopaminergic system, and the sympathetic nervous and renin-angiotensin-aldosterone system: D1 dopamine receptor stimulation-induced vasodilation may activate the sympathetic nervous and renin-angiotensin system in vivo, presynaptic D2 dopamine receptor stimulation is known to inhibit stimulated norepinephrine release from sympathetic nerve terminals, in experimental conditions both in vitro and in vivo. Endogenous dopamine has a tonic inhibitory effect on aldosterone release. Conversely, basal sympathetic activity has been found to be required for the natriuretic effect of dopamine in proximal renal tubules. Other relations include the conversion of dopamine to other catecholamines, and co-release. This review considers the reflection of some of these relations and their clinical significance in man in physiological and pathophysiological conditions, especially congestive heart failure. An inhibitory effect of the nonselective dopamine agonist ibopamine on plasma norepinephrine levels was found in normal man during exercise but not at rest, and in patients with several degrees of congestive heart failure, both at rest and during exercise. Infusions of dopamine 1 μg/kg/min, but not 3μg/kg/min were found to lower plasma norepinephrine levels during sympathetic stimulation by exercise or by a cold pressor test in normal man. Dopamine antagonists enhance the rise in plasma norepinephrine levels during exercise, indicating that endogenous dopamine also inhibits norepinephrine release. Both phentolamine and prazosin abolish the natriuretic effects of dopamine in man, even when the renal hemodynamic effect of dopamine is unaffected. In conclusion, it is important to be aware of clinically significant interactions between the peripheral dopaminergic and sympathetic nervous system at different levels. (Hypertens Res 1995; 18 Suppl. I: S107-S111)

収録刊行物

• Hypertension Research

  Hypertension Research 18 (SupplementI), S107-S111, 1995

  日本高血圧学会

キーワード

• dopamine
• norepinephrine
• congestive heart failure

詳細情報

• CRID: 1390001204719575424
• NII論文ID: 10008735757
• NII論文ID: 130003399321
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.18.supplementi_s107
• ISSN: 13484214
• ISSN: 09169636
• Web Site: https://search.jamas.or.jp/link/ui/1996143677
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可