DA1 Receptor-Mediated Renin Release from Isolated Rat Glomeruli

• Hano Takuzo

  Department of Medicine, Wakayama Medical College

• Shiotani Masahiko

  Department of Medicine, Wakayama Medical College

• Baba Akira

  Department of Medicine, Wakayama Medical College

• Nishio Ichiro

  Department of Medicine, Wakayama Medical College

• Masuyama Yoshiaki

  Tokyo Rosai Hospital

書誌事項

タイトル別名

• DA₁ Receptor-Mediated Renin Release from Isolated Rat Glomeruli

抄録

The present study was performed in order to examine the effects of dopamine (DA) on renin release and to clarify which subtype of DA receptor, DA₁ or DA₂ contributes to renin release. Male Wistar rats aged seven weeks were used. Glomeruli were isolated by the modified Beierwaltes' sieving method and were transferred to a sealed chamber and superfused with Krebs-Ringer solution. In the first experiment, the changes in renin release induced by DA and the effects of a non-selective DA antagonist, haloperidol and a β antagonist, propranolol on DA-induced renin release were examined. In the second experiment, the effect of a DA₂ receptors antagonist, spiperone and of a DA₁ receptor antagonist, SCH-23390 on renin release were investigated. Basal levels of renin release were 2.46± 0.36ng ATI/h/10⁴ glomeruli (mean±SEM). DA caused a dose-dependent increase in renin release. The renin release induced by DA was inhibited by haloperidol but not by propranolol. The maximum level of renin release induced by 10^-5M DA was 4.13±0.63ng ATI/h/10⁴ glomeruli. SCH-23390 at 10^-5M caused significant suppression of DA-induced renin (p<0.05). In contrast, 10^-5M spiperone failed to suppress DA-induced renin release. These results suggest that DA induced renin release from isolated glomeruli through the DA₁ receptors. (Hypertens Res 1995; 18 Suppl. I: S141-S143)

収録刊行物

• Hypertension Research

  Hypertension Research 18 (SupplementI), S141-S143, 1995

  日本高血圧学会

キーワード

• dopamine
• DA₁-receptor
• renin release
• isolated glomerulus

詳細情報

• CRID: 1390001204719536000
• NII論文ID: 10008735932
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.18.supplementi_s141
• ISSN: 13484214
• ISSN: 09169636
• Web Site: https://search.jamas.or.jp/link/ui/1996145046
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可