D-1 Dopamine Receptors Mediate Dopamine-Induced Pancreatic Exocrine Secretion in Anesthetized Dogs

DOI 3 References
  • Iwatsuki Kazuhiko
    the Department of Pharmacology, Shinshu University School of Medicine
  • Horiuchi Akira
    the Department of Pharmacology, Shinshu University School of Medicine
  • Ren Lei-Ming
    the Department of Pharmacology, Shinshu University School of Medicine
  • Chiba Shigetoshi
    the Department of Pharmacology, Shinshu University School of Medicine

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Abstract

Characterization of dopamine (DA) receptor subtypes was examined on the canine exocrine pancreas using selective DA receptor agonists and antagonists in anesthetized dogs. Each drug was injected i.a. in a single bolus fashion. Graded doses of DA (0.01-3μmol) produced dose-dependent increases in the secretory rate of pancreatic juice, with a maximum effect at approximately 1μmol. SCH23390 (3-30nmol), a selective D-1 DA receptor antagonist, caused a progressive parallel shift to the right in the dose-response curve for DA-induced pancreatic secretion without changes in the maximal response. However, domperidone (3μmol), a selective D-2 DA receptor antagonist, did not antagonize the DA-induced pancreatic exocrine secretion. A Schild analysis of the data indicates that the inhibitory constant value for SCH23390 to inhibit DA-stimulated secretion was 6.9nmol. In addition, the stimulatory effects of SKF38393 (0.1-10μmol) and YM435 (0.3-30nmol), selective D-1 DA receptor agonists, and LY171555 (1-10μmol), a selective D-2 DA receptor agonist, on pancreatic secretion were demonstrated. The rank order of agonist potency was YM435>DA>SKF38393_??_LY171555. These results suggest that DA-induced pancreatic exocrine secretion is mediated by activation of D-1 DA receptors. (Hypertens Res 1995; 18 Suppl. I: S173-S174)

Journal

  • Hypertension Research

    Hypertension Research 18 (SupplementI), S173-S174, 1995

    The Japanese Society of Hypertension

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