11β-Hydroxysteroid Dehydrogenase Activity in Human Aortic Smooth Muscle Cells

この論文にアクセスする

この論文をさがす

著者

抄録

11β-Hydroxysteroid dehydrogenases (11β-HSD) interconvert cortisol, the physiological glucocorticoid, and its inactive metabolite cortisone in humans. There are two isoforms. The type 1 isoform (11β-HSD1) catalyzes both 11β-dehydrogenation (cortisol to cortisone) and the reverse oxoreduction (cortisone to cortisol), but the type 2 isoform (11β-HSD2) catalyzes only 11β-dehydrogenation. The diminished dehydrogenase activity has been demonstrated in resistance vessels of genetically hypertensive rats. However, the isoform(s) that plays a significant role in conferring the dehydrogenase activity on vasculature has not been determined. We investigated 11β-HSD activities in human vascular smooth muscle cells by manipulating 11β-HSD expressions with antisense oligonucleotides. The results showed that 11β-HSD2 dominates functioning in the dehydrogenase mode in these cells. This indicates that impairment of 11β-HSD2 activity in vascular wall may be related to the pathogenesis of hypertension. (Hypertens Res 2001; 24: 33-37)

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 24(1), 33-37, 2001-01-01

    The Japanese Society of Hypertension

参考文献:  16件中 1-16件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008741934
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ