Effects of TCV-116 on Endothelin-1 and PDGF A-Chain Expression in Angiotensin II-Induced Hypertensive Rats

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著者

    • HARA Kazuyoshi
    • Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
    • KOBAYASHI Naohiko
    • Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
    • NAKANO Shigefumi
    • Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
    • MORI Yousuke
    • Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
    • TSUBOKOU Yusuke
    • Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine
    • MATSUOKA Hiroaki
    • Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine

抄録

Angiotensin II (Ang II) has been shown to stimulate cardiac growth and collagen synthesis in cultured vascular smooth muscle cells and to increase fibroblast proliferation. Chronic infusion with Ang II increases blood pressure and activates growth mechanisms to produce hypertrophy of the heart. This study investigated the effects of an Ang II type 1 receptor antagonist, TCV-116, on preproendothelin-1 (preproET-1), ET<SUB>A</SUB> receptor and platelet-derived growth factor (PDGF) A-chain expression in the left ventricle of Wistar-Kyoto rats treated for 2 weeks with Ang II (200ng·kg<SUP>-1</SUP>·min<SUP>-1</SUP>), and the relation of these effects to myocardial remodeling. Rats given Ang II alone (ANGII-V) were compared with rats also receiving TCV-116 (ANGII-TCV). In both groups, blood pressure was similar and significantly higher than in control rats. The preproET-1, ET<SUB>A</SUB> receptor and PDGF A-chain expressions in the left ventricle were significantly increased in ANGII-V compared with control rats, and were significantly suppressed in ANGII-TCV compared with ANGII-V rats. ANGII-V rats showed a significant increase of the type I collagen expression, wall-to-lumen ratio, perivascular fibrosis, and myocardial fibrosis, with all these parameters being significantly improved by TCV-116. Myocardial remodeling in Ang II-induced hypertensive rats was significantly ameliorated by a subdepressor dose to TCV-116, which may have been due to a decrease in ET-1 and PDGF A-chain expression in the left ventricle. (Hypertens Res 2001; 24: 55-64)

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 24(1), 55-64, 2001-01-01

    The Japanese Society of Hypertension

参考文献:  53件中 1-53件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008742024
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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