Coronary Capillary Remodeling in Non-Insulin-Dependent Diabetic Rats: Amelioration by Inhibition of Angiotensin Converting Enzyme and Its Potential Clinical Implications

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著者

    • SUGAWARA Taeko
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine
    • FUJII Satoshi
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine
    • AKM ZAMAN Tarikuz
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine
    • GOTO Daisuke
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine
    • KANEKO Takeaki
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine
    • FURUMOTO Tomoo
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine
    • TOGASHI Hiroko
    • Department of Pharmacology, Hokkaido University School of Medicine
    • KOYAMA Tomiyasu
    • Department of Molecular Physiology, Research Institute for Electronic Science, Hokkaido University
    • KITABATAKE Akira
    • Department of Cardiovascular Medicine, Hokkaido University School of Medicine

抄録

Using Otsuka Long Evans Tokushima Fatty (OLETF) rats, a model of human non-insulin-dependent diabetes mellitus (NIDDM) that exhibits hypertension, obesity, hyperglycemia and hyperlipidemia, the role of local angiotensin II in cardiovascular complications at early stages of NIDDM was characterized. OLETF rats were given an angiotensin converting enzyme (ACE) inhibitor, cilazapril (10mg/kg/day) or vehicle from the age of 5 weeks to 20 weeks. Arteriolar, intermediate and venular capillary proportions were determined by the double-staining method and levels of collagen and non-collagenous proteins were determined by the selective dye-binding method in heart tissues. In OLETF rats at 20 weeks of age, capillary network remodeling (I.e., an increase in arteriolar portions and a decrease in venular portions) and an increase in collagen content were detected. Cilazapril not only exerted favorable effects on markers of diabetes, but also prevented capillary network remodeling and ameliorated the increase in collagen content. These results suggest that 1) capillary network remodeling and increase in extracellular matrix protein levels precede the onset of overt NIDDM in OLETF rats, and 2) angiotensin II may be involved in the pathogenesis of cardiac complications in the early stages of NIDDM. (Hypertens Res 2001; 24: 75-81)

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 24(1), 75-81, 2001-01-01

    The Japanese Society of Hypertension

参考文献:  32件中 1-32件 を表示

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各種コード

  • NII論文ID(NAID)
    10008742116
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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