Effect of Long-Acting Isosorbide-5-Mononitrate Administration on Large Artery Distensibility in Patients with Essential Hypertension

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著者

    • WANG Hongyu
    • Department of Cardiology, People's Hospital, Peking University
    • HU Dayi
    • Department of Cardiology, People's Hospital, Peking University
    • SUN Ningling
    • Department of Cardiology, People's Hospital, Peking University
    • GONG Lansheng
    • Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University
    • ZHANG Weizhong
    • Shanghai Institute of Hyperten-sion, Ruijin Hospital, Shanghai Second Medical University

抄録

To evaluate the clinical efficacy of long-acting nitrates, isosorbide-5-mononitrate (IS-5-MN), on large artery distensibility in patients with essential hypertension. Large arterial distensibility was assessed by automatic noninvasive measurement of the carotid-femoral pulse wave velocity (PWV). Seventeen patients aged 62.53±7.94 years (mean±SD) with essential hypertension undering long-term antihypertensive therapy were studied in this trial. PWV was measured 2 weeks and 4 weeks after oral administration of IS-5-MN (30 mg once daily) with previous therapy. There was no significant difference in systolic blood pressure, diastolic blood pressure, pulse pressure or heart rate at 2 weeks and 4 weeks after treatment compared with baseline. The carotid-femoral PWV decreased significantly at 2 and 4 weeks after treatment (<I>p</I><0.05, <I>p</I><0.05, respectively). Long-acting nitrates have potential value in improving large arterial distensibility in patients with essential hypertension independent of blood pressure alteration. It might be used as an effectively additive drug in hypertension control. (Hypertens Res 2001; 24: 311-314)

収録刊行物

  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension

    Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 24(3), 311-314, 2001-05-01

    The Japanese Society of Hypertension

参考文献:  26件中 1-26件 を表示

被引用文献:  6件中 1-6件 を表示

各種コード

  • NII論文ID(NAID)
    10008743101
  • NII書誌ID(NCID)
    AA10847079
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09169636
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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