Catalytic Asymmetric Synthesis of Organofluorine Compounds Using Fluoral.

• Ishii Akihiro

  セントラル硝子 (株) 化学研究所

• Mikami Koichi

  Department of chemical Technology, Tokyo Institute of Technology

Bibliographic Information

Other Title

• フルオラールを用いる含フッ素化合物の触媒的不斉合成
• フルオラール オ モチイル ガン フッソ カゴウブツ ノ ショクバイテキ フセイ ゴウセイ

Abstract

Asymmetric synthesis of organofluorine compounds is an important issue in pharmaceutical chemistry and optoelectronic material science. In this respect, asymmetric catalysis of carboncarbon bond-forming reactions is the most attractive method. Asymmetric catalysis of ene, Mukaiyama-aldol and Friedel-Crafts reactions with fluoral is thus established using chiral binaphthol-derived titanium ((6-Br) -BINOL-Ti) catalysts to provide a practical synthetic route to the organofluorine compounds containing trifluoromethyl group.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 58 (4), 324-333, 2000

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• fluoral
• binaphthol
• chiral titanium catalys
• ene reaction
• aldol reaction
• Friedel-Crafts reaction

Details

• CRID: 1390001205276416384
• NII Article ID: 10008819868
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.58.324
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 5342132
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5342132
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed