モルモット海馬スライスにおけるカルバコール誘導リズム波の長期増強(LTP)に対する効果

• 夏目 季代久

  九州工業大学情報工学部生物化学システム工学科

• 米谷 快男児

  九州工業大学情報工学部生物化学システム工学科

書誌事項

タイトル別名

• The Effects of Rhythmical Waves Induced by Carbachol on LTP in Guinea Pig Hippocampal Slices

抄録

The cholinergic input to the hippocampus originates in the septum and diagonal band. A bath application of carbachol, a cholinergic agonist, induced different patterns of rhythmical waves depending on its concentration in guinea pig hippocampal slices. Tetanus-induced long-term potentiation (LTP) was differentially facilitated under several concentrations of carbachol. Under the concentrations, which were within the optimum range for generating theta-like waves, LTP was most facilitated. In addition, the higher augmentation of LTP occurred when LTP was induced during the generation of theta-like wave. These results suggested that depending on the activity of the cholinergic septal input to hippocampus, different patterns of rhythmical waves are induced and the plasticity in hippocampal neural networks can be modulated by them.

収録刊行物

• 日本神経回路学会誌

  日本神経回路学会誌 3 (4), 135-140, 1996

  日本神経回路学会

詳細情報

• CRID: 1390001204467473408
• NII論文ID: 10008841212
• NII書誌ID: AA11658570
• DOI: 10.3902/jnns.3.135
• ISSN: 18830455
• ISSN: 1340766X
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可