The Effects of Rhythmical Waves Induced by Carbachol on LTP in Guinea Pig Hippocampal Slices

• Natsume Kiyohisa

  Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology

• Kometani Kaoru

  Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology

Bibliographic Information

Other Title

• モルモット海馬スライスにおけるカルバコール誘導リズム波の長期増強(LTP)に対する効果

Abstract

The cholinergic input to the hippocampus originates in the septum and diagonal band. A bath application of carbachol, a cholinergic agonist, induced different patterns of rhythmical waves depending on its concentration in guinea pig hippocampal slices. Tetanus-induced long-term potentiation (LTP) was differentially facilitated under several concentrations of carbachol. Under the concentrations, which were within the optimum range for generating theta-like waves, LTP was most facilitated. In addition, the higher augmentation of LTP occurred when LTP was induced during the generation of theta-like wave. These results suggested that depending on the activity of the cholinergic septal input to hippocampus, different patterns of rhythmical waves are induced and the plasticity in hippocampal neural networks can be modulated by them.

Journal

• The Brain & Neural Networks

  The Brain & Neural Networks 3 (4), 135-140, 1996

  Japanese Neural Network Society

Details

• CRID: 1390001204467473408
• NII Article ID: 10008841212
• NII Book ID: AA11658570
• DOI: 10.3902/jnns.3.135
• ISSN: 18830455
• ISSN: 1340766X
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed