Cyclodextrin Precipitates with Normal Alcohols in an Aqueous Medium and Their Stability on Being Left Standing in Air.

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  • Sanemasa Isao
    Department of Chemistry, Faculty of Science, Kumamoto University
  • Wu Ji-Shi
    Department of Chemistry, Faculty of Science, Kumamoto University
  • Toda Kei
    Department of Chemistry, Faculty of Science, Kumamoto University

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  • Cyclodextrin Precipitates with Normal A

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Abstract

Cyclodextrin (CyD) precipitates with normal alcohols (guests, 1-butanol to 1-decanol) were prepared at 25 °C by introducing an alcohol vapor into an aqueous CyD solution and circulating it in a closed system. The guest/CyD molar ratio of the precipitates was measured immediately after preparation and after having been allowed to stand in air at room temperature for 30 or 40 d. Precipitates were obtained with alcohols higher than 1-pentanol for α-CyD, 1-hexanol for β-CyD, and 1-butanol for γ-CyD. The reason that CyD does not precipitate with lower alcohols could be explained in terms of the solubility product. There was a linear relationship between the apparent solubility (derived from the solubility product) of the CyD precipitates in water and the guest–CyD association constant. Upon drying in air, the guest/CyD molar ratio in the precipitates gradually decreased with days allowed to stand. In the cases of α- and γ-CyDs, the ratio remained constant after one week.

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