Specific Deuterium Labeling of Archaeal 36-Membered Macrocyclic Diether Lipid

• Arakawa Kenji

  Department of Chemistry, Tokyo Institute of Technology

• Eguchi Tadashi

  Department of Chemistry, Tokyo Institute of Technology

• Kakinuma Katsumi

  Department of Chemistry, Tokyo Institute of Technology

書誌事項

タイトル別名

• Specific Deuterium Labeling of Archaeal

抄録

Described in this paper is a practical synthesis of the specifically deuterated 36-membered macrocyclic diether lipid 4 and its acyclic deuterated counterpart 5, both of which are essential to the detailed biophysical studies of the conformational order of phospholipids in vesicles. The synthesis of 4 was principally composed of the preparation of deuterated diether 15, subsequent macrocyclization of the crucial dialdehyde 21 by McMurry coupling, and final transformation into the phosphocholine derivative. The acyclic deuterated counterpart 5 was also synthesized from the common intermediary tosylate 16.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 71 (10), 2419-2426, 1998

  公益社団法人 日本化学会

キーワード

• General Chemistry

詳細情報

• CRID: 1390282679097334400
• NII論文ID: 130004149937
• NII論文ID: 10008937559
• NII書誌ID: AA00580132
• DOI: 10.1246/bcsj.71.2419
• ISSN: 13480634
• ISSN: 00092673
• NDL書誌ID: 4583848
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4583848
• Web Site: https://academic.oup.com/bcsj/article-pdf/71/10/2419/56196950/bcsj.71.2419.pdf
• 本文言語コード: en
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